The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 1997
Should ethambutol be recommended for routine treatment of tuberculosis in children? A review of the literature.
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Trébucq A
Аннотация
SETTING: Review of the literature referenced from Medline and other sources on the use of ethambutol in children.
OBJECTIVE: The most well-known side effect of ethambutol is its ocular toxicity. Its use among children is thus generally discouraged. The present article summarizes the studies published on this subject.
RESULTS: No authors have reported major ocular side effects among children treated with ethambutol.
CONCLUSION: For children aged 5 years or more, ethambutol can be recommended at a dosage of 15 mg/kg/day for routine treatment, without taking more precautions than for adults; this should be included in official recommendations. For younger children, ethambutol can also be used without undue fear of side-effects.
OBJECTIVE: The most well-known side effect of ethambutol is its ocular toxicity. Its use among children is thus generally discouraged. The present article summarizes the studies published on this subject.
RESULTS: No authors have reported major ocular side effects among children treated with ethambutol.
CONCLUSION: For children aged 5 years or more, ethambutol can be recommended at a dosage of 15 mg/kg/day for routine treatment, without taking more precautions than for adults; this should be included in official recommendations. For younger children, ethambutol can also be used without undue fear of side-effects.