Neuroscience and biobehavioral reviews · 2025
Person-centered noninvasive brain stimulation for aging-related neurological and mental disorders: A multi-dimensional framework for designing protocols.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Sa, Keller Corey J, Chen Nai-Feng, Adeli Ehsan, Lin F Vankee
Аннотация
BACKGROUND: Noninvasive brain stimulation (NIBS) shows significant promise for treating aging-related neurological and mental disorders (ANMDs). However, its clinical benefits vary widely across individuals due to the highly heterogeneous nature of patient traits and states. Person-centered NIBS - defined as stimulation protocols tailored to the inter- and intra-individual variability in brain structure, function, and behavioral context - may help address this heterogeneity and enhance the clinical benefits of NIBS. While current clinical guidelines provide evidence-based standards for managing complex clinical realities and guiding practitioners, existing personalization strategies are isolated and lack a systematic framework needed to design truly person-centered NIBS.
OBJECTIVE: We propose a multi-dimensional framework for person-centered NIBS protocol designs, systematically targeting inter-individual differences and intra-individual variations in patients, to enhance the availability and engagement of neural resources supporting the improvement of cognition, mood, and motor functions in ANMDs.
METHODS AND FRAMEWORK: We provide a systematic review of current personalization strategies and the efficacy of personalized NIBS in ANMDs. We then presented a multi-dimensional conceptual framework of person-centered NIBS intended to guide future protocol development for systematically targeting inter-individual differences and intra-individual variations in patients. Complementing this, the operational framework provides a perspective-based, structured approach to personalize NIBS target and dosage (stimulation parameters and session scheduling), encompassing (1) structural and functional neuroimaging for target localization and parameter initialization, (2) closed-loop NIBS with multimodal neurobehavioral monitoring for real-time parameter adjustment, (3) dose-response modeling for between-session parameter adaption, and (4) complementary pharmacological and behavioral interventions.
IMPLICATIONS: We envision that the proposed multi-dimensional framework could guide person-centered NIBS with enhanced effectiveness of NIBS in ANMDs.
OBJECTIVE: We propose a multi-dimensional framework for person-centered NIBS protocol designs, systematically targeting inter-individual differences and intra-individual variations in patients, to enhance the availability and engagement of neural resources supporting the improvement of cognition, mood, and motor functions in ANMDs.
METHODS AND FRAMEWORK: We provide a systematic review of current personalization strategies and the efficacy of personalized NIBS in ANMDs. We then presented a multi-dimensional conceptual framework of person-centered NIBS intended to guide future protocol development for systematically targeting inter-individual differences and intra-individual variations in patients. Complementing this, the operational framework provides a perspective-based, structured approach to personalize NIBS target and dosage (stimulation parameters and session scheduling), encompassing (1) structural and functional neuroimaging for target localization and parameter initialization, (2) closed-loop NIBS with multimodal neurobehavioral monitoring for real-time parameter adjustment, (3) dose-response modeling for between-session parameter adaption, and (4) complementary pharmacological and behavioral interventions.
IMPLICATIONS: We envision that the proposed multi-dimensional framework could guide person-centered NIBS with enhanced effectiveness of NIBS in ANMDs.