Journal of the American Academy of Child and Adolescent Psychiatry · 2010
Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Antshel Kevin M, Shprintzen Robert, Fremont Wanda, Higgins Anne Marie, Faraone Stephen V, Kates Wendy R
Аннотация
OBJECTIVE: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS).
METHOD: A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points.
RESULTS: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test.
CONCLUSIONS: Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention.
METHOD: A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points.
RESULTS: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test.
CONCLUSIONS: Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention.
Предметные рубрики MeSH
AdolescentAdolescent PsychiatryAnxiety DisordersAttentionAttention Deficit and Disruptive Behavior DisordersCausalityChildChild PsychiatryCognitionMajor Depressive DisorderDiGeorge SyndromeEducational StatusExecutive FunctionFollow-Up StudiesHumansIntelligenceMemoryParentsPsychiatric Status Rating ScalesPsychological TestsPsychotic Disorders