Microcirculation (New York, N.Y. : 1994) · 2026
Modeling Pressure-Dependent Wave and Vessel Compliance in the Brain Following Middle Cerebral Artery Occlusion.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhao Erin, Barber Jared, Mathew-Steiner Shomita S, Khanna Savita, Sen Chandan K, Arciero Julia
Аннотация
OBJECTIVE: This study demonstrates the impact of alterations in pressure, vascular compliance, arterial pulsatility, and autoregulation on tissue perfusion following middle cerebral artery (MCA) occlusion using mathematical modeling.
METHODS: Our previous mathematical model of the cerebral circulation is expanded to include vessel compliance and pulsatility of blood flow. An experimentally-obtained pressure waveform is used as an incoming boundary condition to simulate the effects of vascular compliance and pulsatility of flow on perfusion following MCA occlusion. The waveform is adjusted to model the effects of elevated mean arterial pressure.
RESULTS: Increased distensibility reduces the amplitude of oscillations in the time-dependent pressure solutions, whereas decreased distensibility produces more variation in these pressures. Occlusion significantly alters the magnitude of flow changes when incoming pressure is varied. The addition of the pulsatile pressure boundary condition and capacitances in the arteries and veins shifts the autoregulation plateau to higher pressures.
CONCLUSIONS: This study reveals how changes in incoming pressure affect compensatory responses to ischemic stroke caused by MCA occlusion. Boundary conditions corresponding to elevated mean arterial pressures are associated with lower degrees of ischemia, an improvement that is supported by changes in autoregulation patterns following occlusion. The results also demonstrate how increases in arterial stiffness associated with aging can inhibit the ability of the vasculature to accommodate pulsatile flow by analyzing resulting patterns such as larger amplitudes of pressure and flow oscillations in the microcirculation. The study provides a foundation for modeling the relationships among vessel compliance, arterial blood pressure, and cerebrovascular conditions.
METHODS: Our previous mathematical model of the cerebral circulation is expanded to include vessel compliance and pulsatility of blood flow. An experimentally-obtained pressure waveform is used as an incoming boundary condition to simulate the effects of vascular compliance and pulsatility of flow on perfusion following MCA occlusion. The waveform is adjusted to model the effects of elevated mean arterial pressure.
RESULTS: Increased distensibility reduces the amplitude of oscillations in the time-dependent pressure solutions, whereas decreased distensibility produces more variation in these pressures. Occlusion significantly alters the magnitude of flow changes when incoming pressure is varied. The addition of the pulsatile pressure boundary condition and capacitances in the arteries and veins shifts the autoregulation plateau to higher pressures.
CONCLUSIONS: This study reveals how changes in incoming pressure affect compensatory responses to ischemic stroke caused by MCA occlusion. Boundary conditions corresponding to elevated mean arterial pressures are associated with lower degrees of ischemia, an improvement that is supported by changes in autoregulation patterns following occlusion. The results also demonstrate how increases in arterial stiffness associated with aging can inhibit the ability of the vasculature to accommodate pulsatile flow by analyzing resulting patterns such as larger amplitudes of pressure and flow oscillations in the microcirculation. The study provides a foundation for modeling the relationships among vessel compliance, arterial blood pressure, and cerebrovascular conditions.