Cancer · 1993
Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese.
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Nakamura S, Suchi T, Koshikawa T, Suzuki H, Oyama A, Kojima M, Motoori T, Ueda R, Takahashi T
Аннотация
BACKGROUND: Postthymic/peripheral T-cell malignancy shows significant histopathologic and clinical diversity, even in its prognosis, and the correlations remain to be debated.
METHODS: The clinicopathologic features of 212 Japanese patients with these neoplasms were investigated.
RESULTS: There were 131 male and 81 female patients, whose ages ranged from 2 to 90 years (mean, 51.7 years). Lymphadenopathy was the most frequent clinical presentation, and the patients also had frequent skin lesions, hyperimmunoglobulinemia, hypercalcemia, and a rapid clinical course. Furthermore, the differences in the histologic features of each subcategory reflected the clinical pictures. The immunophenotypic analysis was indispensable in establishing a correct diagnosis, and the high-grade tumors often showed loss of pan-T antigens.
CONCLUSIONS: The histopathologic classification proposed by Suchi et al., which has been incorporated into the updated Kiel classification, showed a good prognostic correlation.
METHODS: The clinicopathologic features of 212 Japanese patients with these neoplasms were investigated.
RESULTS: There were 131 male and 81 female patients, whose ages ranged from 2 to 90 years (mean, 51.7 years). Lymphadenopathy was the most frequent clinical presentation, and the patients also had frequent skin lesions, hyperimmunoglobulinemia, hypercalcemia, and a rapid clinical course. Furthermore, the differences in the histologic features of each subcategory reflected the clinical pictures. The immunophenotypic analysis was indispensable in establishing a correct diagnosis, and the high-grade tumors often showed loss of pan-T antigens.
CONCLUSIONS: The histopathologic classification proposed by Suchi et al., which has been incorporated into the updated Kiel classification, showed a good prognostic correlation.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntigens, Differentiation, T-LymphocyteChildChild, PreschoolDiagnosis, DifferentialFemaleHTLV-I AntibodiesHumansImmunohistochemistryJapanLymphoma, Non-HodgkinLymphoma, T-Cell, CutaneousLymphoma, T-Cell, PeripheralMaleMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellSurvival Rate