Methodology for the development of the Clinical guideline for the diagnosis and treatment of precocious puberty.
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Torres-Tamayo Margarita, Zurita-Cruz Jessie N, Aguilar-Herrera Blanca E, Miranda-Lora América L, Calzada-León Raúl, Rivera-Hernández Aleida J, Morales-Pérez Marco A, Padrón-Martínez Miriam M, Ruiz-Reyes María L, García-Morales Leticia M, Barrón-Uribe Consuelo, Arguinzoniz-Valenzuela Sletza L, Torres-Castañeda Mayra C, Lizárraga-Paulin Lorena, Núñez-Hernández Jorge A, Cornejo-Barrera Judith, Vidal-González María T, Martínez-Alvarado María R, Nishimura-Meguro Elisa, Bravo-Ríos Luz E, Garrido-Magaña Eulalia P, Orozco-Morales José A, Medina-Bravo Patricia G, Coyote-Estrada Ninel, Castilla-Peón M Fernanda
Аннотация
METHODS: Three systematic reviews were conducted: controlled clinical trials on interventions for PP treatment, diagnostic tests, and observational studies on the long-term effects of PP. The quality evaluation and data extraction from the studies were conducted by two independent reviewers. The Scottish Intercollegiate Guidelines Network and the Oxford Center for Evidence-Based Medicine systems were used for grading the quality of evidence for recommendations on intervention and diagnosis, respectively. Recommendations were submitted to a consensus by a Delphi method and were validated by another 143 certified pediatric endocrinologists through an online questionnaire.
RESULTS: The group generated 12 recommendations on the diagnosis of PP, seven on the diagnosis of secondary causes of PP, eight on interventions for inhibition of puberty, five on other interventions for PP treatment, and 14 for the monitoring and follow-up of these patients. The online questionnaires submitted to certified pediatric endocrinologists showed more than 90% of approval for each one of the recommendations.
CONCLUSIONS: Although a high degree of consensus for the recommendations for diagnosis, treatment, and monitoring of PP among pediatric endocrinologists was achieved, most of these recommendations showed a low level of evidence.