Veterinary medicine and science · 2025
Efficacy of Dietary Cottonseed Bioactive Peptides Compared to Diclazuril or Salinomycin on Reducing Adverse Effects of Coccidiosis Challenge in Broiler Chickens.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Yazdani Mohammad Reza, Kheiri Farshid, Faghani Mostafa, Sharifzadeh Ali
Аннотация
BACKGROUND: Bioactive peptides present antimicrobial, antioxidative and immunomodulatory activities with beneficial effects on broiler chickens.
OBJECTIVES: This experiment was conducted to examine the influence of dietary supplemental cottonseed bioactive peptides (CBP) on growth performance, oocysts per gram of faeces (OPG), intestinal morphology, immune responses and interleukin-6 (IL-6) gene expression in broilers exposed to coccidial infection.
METHODS: A total of 420 broiler chicks (Ross 308) were assigned to seven dietary treatments in a completely randomized design during 10-45 days of age. Experimental treatments included: (1) CON+, broiler chickens without challenge; (2) CON-, birds challenged with coccidiosis; (3-5) the CON- birds fed diets containing 4 g/kg, 5 g/kg or 6 g/kg CBP, respectively; (6) the CON- birds fed diets containing 0.2 g/kg diclazuril; (7) the CON- birds fed diets containing 0.5 g/kg salinomycin.
RESULTS: Infection alleviated daily feed intake and growth of broilers fed a basal diet during 31-38 days of age (p < 0·05), which ameliorated after supplementation of 6 g/kg CBP (p < 0.05). Dietary 4 or 6 g/kg CBP, diclazuril or salinomycin compensated for the impairment in the feed conversion ratio of Eimeria spp. challenged broilers during 31-45 days of age (p < 0.05). Coccidiosis challenge increased OPG; however, the OPG value decreased when the diet contained CBP or anti-coccidiosis drugs (p < 0.05). Antibody titer against sheep red blood cells improved in challenged birds fed 6 g/kg CBP (p < 0.05).
CONCLUSIONS: Dietary CBP decreased the negative effects of coccidiosis, whereby supplemented birds had similar immune responses or even better growth performance than birds receiving anticoccidials.
OBJECTIVES: This experiment was conducted to examine the influence of dietary supplemental cottonseed bioactive peptides (CBP) on growth performance, oocysts per gram of faeces (OPG), intestinal morphology, immune responses and interleukin-6 (IL-6) gene expression in broilers exposed to coccidial infection.
METHODS: A total of 420 broiler chicks (Ross 308) were assigned to seven dietary treatments in a completely randomized design during 10-45 days of age. Experimental treatments included: (1) CON+, broiler chickens without challenge; (2) CON-, birds challenged with coccidiosis; (3-5) the CON- birds fed diets containing 4 g/kg, 5 g/kg or 6 g/kg CBP, respectively; (6) the CON- birds fed diets containing 0.2 g/kg diclazuril; (7) the CON- birds fed diets containing 0.5 g/kg salinomycin.
RESULTS: Infection alleviated daily feed intake and growth of broilers fed a basal diet during 31-38 days of age (p < 0·05), which ameliorated after supplementation of 6 g/kg CBP (p < 0.05). Dietary 4 or 6 g/kg CBP, diclazuril or salinomycin compensated for the impairment in the feed conversion ratio of Eimeria spp. challenged broilers during 31-45 days of age (p < 0.05). Coccidiosis challenge increased OPG; however, the OPG value decreased when the diet contained CBP or anti-coccidiosis drugs (p < 0.05). Antibody titer against sheep red blood cells improved in challenged birds fed 6 g/kg CBP (p < 0.05).
CONCLUSIONS: Dietary CBP decreased the negative effects of coccidiosis, whereby supplemented birds had similar immune responses or even better growth performance than birds receiving anticoccidials.