Journal of ethnopharmacology · 2025
Syagrus vagans (Bondar) Hawkes seed oil has a safe use, provides a protective effect against methyl methanesulfonate-induced DNA damage, and alleviates pain and inflammation in mice.
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da Silva Jeanderson Marcelino, da Silva Wesly Mikael, da Silva Meykson Alexandre, de Lima José Rivaldo, de Lima Júnior Nelson Correia, de Santana Jonata Henrique, Fernandes Mariana Pinheiro, da Silva Teresinha Gonçalves, Chagas Cristiano Aparecido, de Aguiar Júnior Francisco Carlos Amanajás, Ferraz Navarro Daniela Maria do Amaral, Galdino Dos Santos Fábio Henrique, de Oliveira Alves João Victor, da Silva Márcia Vanusa, Correia Maria Tereza Dos Santos
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Syagrus vagans, known popularly as Ariri, is a palm found in the Caatinga, whose seed oil has been utilized therapeutically to relieve various health conditions. However, ethnopharmacological research on its efficacy and safety remains scarce.
AIM OF THE STUDY: The study aimed to describe fatty acid profile of S. vagans fixed oil (SvO), as well as toxicological evaluation and its pharmacological activities, including antigenotoxicity, antimutagenicity, antinociceptive, and anti-inflammatory.
MATERIALS AND METHODS: Initially, the fixed oil was analyzed by GC-FID. HCT-116 and RAW 264.7 cell lines were seeded in microplates with SvO, and cell viability was evaluated through the MTT colorimetric method. Acute toxicity, genotoxicity, and mutagenicity were assessed after the administration of a single dose of SvO (2000 mg/kg per os) in mice. SvO was also evaluated for antigenotoxicity and antimutagenicity in a model of methyl methanesulfonate (MMS)-induced genetic damage in vivo. The antinociceptive and anti-inflammatory properties of SvO were evaluated by abdominal writhing, formalin, carrageenan-induced paw edema, and peritonitis tests conducted in mice.
RESULTS: The fatty acid profile of SvO revealed that the major components were lauric acid, palmitic acid, and linoleic acid. The IC50 of SvO for HCT-116 and RAW 264.7 exceeded 200 μg/mL and 196.8 μg/mL, respectively. Acute toxicity, genotoxicity, and mutagenicity assessments in mice revealed no mortality, behavioral changes, biochemical alterations, histopathological damage to organs, or impacts on genetic material. SvO protected the DNA from damage induced by MMS. There was a dose-dependent reduction in the number of abdominal writhings induced by acetic acid, as well as a decreased licking duration in the first and second phases of the formalin test. Furthermore, SvO demonstrated an anti-edematogenic effect in carrageenan-induced edema and a significant decrease in the migration of neutrophils, leukocytes, IL-1β, and TNF-α in the peritonitis assay.
CONCLUSION: Ingestion of SvO proved to be safe, protected DNA from damage induced by methyl methanesulfonate, as well as exhibited antinociceptive and anti-inflammatory effects.
AIM OF THE STUDY: The study aimed to describe fatty acid profile of S. vagans fixed oil (SvO), as well as toxicological evaluation and its pharmacological activities, including antigenotoxicity, antimutagenicity, antinociceptive, and anti-inflammatory.
MATERIALS AND METHODS: Initially, the fixed oil was analyzed by GC-FID. HCT-116 and RAW 264.7 cell lines were seeded in microplates with SvO, and cell viability was evaluated through the MTT colorimetric method. Acute toxicity, genotoxicity, and mutagenicity were assessed after the administration of a single dose of SvO (2000 mg/kg per os) in mice. SvO was also evaluated for antigenotoxicity and antimutagenicity in a model of methyl methanesulfonate (MMS)-induced genetic damage in vivo. The antinociceptive and anti-inflammatory properties of SvO were evaluated by abdominal writhing, formalin, carrageenan-induced paw edema, and peritonitis tests conducted in mice.
RESULTS: The fatty acid profile of SvO revealed that the major components were lauric acid, palmitic acid, and linoleic acid. The IC50 of SvO for HCT-116 and RAW 264.7 exceeded 200 μg/mL and 196.8 μg/mL, respectively. Acute toxicity, genotoxicity, and mutagenicity assessments in mice revealed no mortality, behavioral changes, biochemical alterations, histopathological damage to organs, or impacts on genetic material. SvO protected the DNA from damage induced by MMS. There was a dose-dependent reduction in the number of abdominal writhings induced by acetic acid, as well as a decreased licking duration in the first and second phases of the formalin test. Furthermore, SvO demonstrated an anti-edematogenic effect in carrageenan-induced edema and a significant decrease in the migration of neutrophils, leukocytes, IL-1β, and TNF-α in the peritonitis assay.
CONCLUSION: Ingestion of SvO proved to be safe, protected DNA from damage induced by methyl methanesulfonate, as well as exhibited antinociceptive and anti-inflammatory effects.