Neuropathology and applied neurobiology · 2012
S100β as a novel and accessible indicator for the presence of monocyte-driven encephalitis in AIDS.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Renner N A, Redmann R K, Moroney-Rasmussen T, Sansing H A, Aye P P, Didier P J, Lackner A A, Maclean A G
Аннотация
AIMS: The pathogenesis of human/simian immunodeficiency virus encephalitis (HIVE/SIVE) remains incompletely understood, but is associated with alterations in the blood-brain barrier. At present, it is not possible to easily determine if an individual has HIVE/SIVE before post mortem examination.
METHODS: We have examined serum levels of the astroglial protein S100β in SIV-infected macaques and show that it can be used to determine which animals have SIVE. We also checked for correlations with inflammatory markers such as CCL2/MCP-1, IL-6 and C-reactive protein.
RESULTS: We found that increased S100β protein in serum correlated with decreased expression of the tight junction protein zonula occludens-1 on brain microvessels. Furthermore, the decrease in zonula occludens-1 expression was spatially related to SIVE lesions and perivascular deposition of plasma fibrinogen. There was no correlation between encephalitis and plasma levels of IL-6, MCP-1/CCL2 or C-reactive protein.
CONCLUSIONS: Together, these data indicate that SIVE lesions are associated with vascular leakage that can be determined by S100β protein in the periphery. The ability to simply monitor the presence of SIVE will greatly facilitate studies of the neuropathogenesis of AIDS.
METHODS: We have examined serum levels of the astroglial protein S100β in SIV-infected macaques and show that it can be used to determine which animals have SIVE. We also checked for correlations with inflammatory markers such as CCL2/MCP-1, IL-6 and C-reactive protein.
RESULTS: We found that increased S100β protein in serum correlated with decreased expression of the tight junction protein zonula occludens-1 on brain microvessels. Furthermore, the decrease in zonula occludens-1 expression was spatially related to SIVE lesions and perivascular deposition of plasma fibrinogen. There was no correlation between encephalitis and plasma levels of IL-6, MCP-1/CCL2 or C-reactive protein.
CONCLUSIONS: Together, these data indicate that SIVE lesions are associated with vascular leakage that can be determined by S100β protein in the periphery. The ability to simply monitor the presence of SIVE will greatly facilitate studies of the neuropathogenesis of AIDS.
Предметные рубрики MeSH
Acquired Immunodeficiency SyndromeAnimalsBiomarkersBlood-Brain BarrierBrainC-Reactive ProteinChemokine CCL2Encephalitis, ViralInterleukin-6Macaca mulattaMembrane ProteinsMonocytesNerve Growth FactorsPhosphoproteinsS100 Calcium Binding Protein beta SubunitS100 ProteinsSimian Immunodeficiency VirusTight JunctionsZonula Occludens-1 Protein