Медицинская библиотека · Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2000

[Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar].

Wu J, Chen D, Wu Z

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the expression of mRNA for TGF-beta, MMP-1 and TIMP-1 and their effects on the formation of hypertrophic scar (HTS).

METHODS

In situ hybridization and image analysis were used in this study.

RESULTS

The expressions of mRNA for TGF-beta and TIMP-1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF-beta and TIMP-1 increased by 8 and 7 folds (P < 0.001) related to normal skin and the expression of them showed highly positive correlation.

CONCLUSIONS

The findings suggest that TGF-beta promotes the expression of TIMP-1 and may be a possible factor for hypertrophic scar formation.

Для цитирования: Wu J, Chen D, Wu Z. [Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar].. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 2000.

Предметные рубрики MeSH

Adolescent Adult Child Cicatrix, Hypertrophic Collagenases Female Humans Male Matrix Metalloproteinase 1 RNA, Messenger Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta

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