Voprosy onkologii · 2010
[Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors].
Клиническое исследованиеАннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Ismail-Zade R S, Zhavrid E A, Aleĭnikova O V, Potapnev M P, Belevtsev M V, Isaĭkina Ia I, Vashkevich E P, Savitskiĭ V P
Аннотация
Tentative results of LAK-cell and whole-body hyperthermia (WBH) were evaluated in 19 children with advanced chemorefractory tumors. LAK-cells were obtained by extracorporeal incubation of peripheral blood lymphocytes: a germ-cell rhabdomyosarcoma was detected in 4, Askin's tumor--2--2, renal cell carcinoma--2 and miscellaneous--7. Autologous LAK-cells were infused twice: on completion of WBH as body temperature fell to as low as (+) 40 deg. C and on day after WBH. The latter was well tolerated. Complete or partial response to thermochemobiotherapy was reported in 8 patients. Overall 5-year survival was 43% (median follow-up--12.6 months).
Предметные рубрики MeSH
AdolescentAntineoplastic AgentsBody TemperatureCarcinoma, Renal CellChildChild, PreschoolCombined Modality TherapyFemaleFollow-Up StudiesHumansHyperthermia, InducedImmunotherapy, AdoptiveKiller Cells, Lymphokine-ActivatedMaleNeoplasmsNeoplasms, Germ Cell and EmbryonalNeuroectodermal TumorsRhabdomyosarcoma, EmbryonalSurvival AnalysisTransplantation, AutologousTreatment Outcome