[Immunoelectrophorogram and serum levels of immunoglobulins G, A and M in automobile tire factory workers].

Electrophoresis and immunoelectrophoresis of serum proteins and concentrations of IgG, IgA and IgM in serum were estimated in 87 rubber tire workers producing rubber mixtures (44 males) and tubes (25 males and 18 females). The total serum protein concentration, as compared with controls, was not changed, however the percentage of gamma globulins was elevated and that of albumins and alpha and beta globulins reduced. The immunoelectrophoretic distribution frequently showed a rise of acute phase proteins and immunoglobulins, most frequently those of IgG and IgA. Quantitative determinations showed a significant rise of serum IgG and IgA and in workers employed at the production of rubber mixtures also a fall of IgM concentrations, as compared to control groups.