Annals of internal medicine · 1996
Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle.
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Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanagihara N
Аннотация
OBJECTIVE: To determine whether herpes simplex virus type 1 (HSV-1) causes Bell palsy.
DESIGN: Prospective study.
SETTING: University inpatient service.
PATIENTS: 14 patients with Bell palsy, 9 patients with the Ramsay-Hunt syndrome, and 12 other controls.
MEASUREMENTS: Viral genomes of HSV-1, varicella-zoster virus, and Epstein-Barr virus were analyzed in clinical samples of facial nerve endoneurial fluid and posterior auricular muscle using polymerase chain reaction (PCR) followed by hybridization with Southern blot analysis.
RESULTS: Herpes simplex virus type 1 genomes were detected in 11 of 14 patients (79%) with Bell palsy but not in patients with the Ramsay-Hunt syndrome or in other controls. The nucleotide sequences of the PCR fragments were identical to those of the HSV-1 genome.
CONCLUSIONS: Herpes simplex virus type 1 is the major etiologic agent in Bell palsy.
DESIGN: Prospective study.
SETTING: University inpatient service.
PATIENTS: 14 patients with Bell palsy, 9 patients with the Ramsay-Hunt syndrome, and 12 other controls.
MEASUREMENTS: Viral genomes of HSV-1, varicella-zoster virus, and Epstein-Barr virus were analyzed in clinical samples of facial nerve endoneurial fluid and posterior auricular muscle using polymerase chain reaction (PCR) followed by hybridization with Southern blot analysis.
RESULTS: Herpes simplex virus type 1 genomes were detected in 11 of 14 patients (79%) with Bell palsy but not in patients with the Ramsay-Hunt syndrome or in other controls. The nucleotide sequences of the PCR fragments were identical to those of the HSV-1 genome.
CONCLUSIONS: Herpes simplex virus type 1 is the major etiologic agent in Bell palsy.