The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2012
Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis.
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Wu Aimin, Zhong Xiaonan, Wang Honghao, Xu Wen, Cheng Chen, Dai Yongqiang, Bao Jian, Qiu Wei, Lu Zhengqi, Hu Xueqiang
Аннотация
BACKGROUND: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown.
OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity.
METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16).
RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027).
CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.
OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity.
METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16).
RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027).
CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.