Archives of neurology · 2011
Neuromyelitis optica with extensive active brain involvement: an autopsy study.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Almekhlafi Mohammed A, Clark Arthur W, Lucchinetti Claudia F, Zhang Yunyan, Power Christopher, Bell Robert B
Аннотация
OBJECTIVE: To describe the clinical, molecular, and neuropathological findings of a patient with aquaporin 4-positive relapsing myelitis who developed extensive brain involvement followed by death.
DESIGN: Case report.
SETTING: Foothills Medical Center, Calgary, Alberta, Canada.
PATIENT: A 51-year-old woman with neuromyelitis optica spectrum disorder.
RESULTS: Neuropathological examination disclosed neuromyelitis optica lesions, even in areas that appeared normal radiologically and grossly. Immunostaining confirmed the massive disintegration of astrocytes in the acute and chronic lesions, indicating that astrocytes are targeted early in the disease process. Induction of the immune response was demonstrated by reverse-transcriptase polymerase chain reaction analysis of relevant immune response genes.
CONCLUSIONS: This article supports and supplements current concepts of astrocyte disintegration in neuromyelitis optica and of immune mechanisms in its pathogenesis.
DESIGN: Case report.
SETTING: Foothills Medical Center, Calgary, Alberta, Canada.
PATIENT: A 51-year-old woman with neuromyelitis optica spectrum disorder.
RESULTS: Neuropathological examination disclosed neuromyelitis optica lesions, even in areas that appeared normal radiologically and grossly. Immunostaining confirmed the massive disintegration of astrocytes in the acute and chronic lesions, indicating that astrocytes are targeted early in the disease process. Induction of the immune response was demonstrated by reverse-transcriptase polymerase chain reaction analysis of relevant immune response genes.
CONCLUSIONS: This article supports and supplements current concepts of astrocyte disintegration in neuromyelitis optica and of immune mechanisms in its pathogenesis.