The Journal of clinical investigation · 2024
MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells.
Рандомизированное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Röring Rutger J, Debisarun Priya A, Botey-Bataller Javier, Suen Tsz Kin, Bulut Özlem, Kilic Gizem, Koeken Valerie Acm, Sarlea Andrei, Bahrar Harsh, Dijkstra Helga, Lemmers Heidi, Gössling Katharina L, Rüchel Nadine, Ostermann Philipp N, Müller Lisa, Schaal Heiner, Adams Ortwin, Borkhardt Arndt, Ariyurek Yavuz, de Meijer Emile J, Kloet Susan L, Ten Oever Jaap, Placek Katarzyna, Li Yang, Netea Mihai G
Аннотация
The measles, mumps, and rubella (MMR) vaccine protects against all-cause mortality in children, but the immunological mechanisms mediating these effects are poorly known. We systematically investigated whether MMR can induce long-term functional changes in innate immune cells, a process termed trained immunity, that could at least partially mediate this heterologous protection. In a randomized, placebo-controlled trial, 39 healthy adults received either the MMR vaccine or a placebo. Using single-cell RNA-Seq, we found that MMR caused transcriptomic changes in CD14+ monocytes and NK cells, but most profoundly in γδ T cells. Monocyte function was not altered by MMR vaccination. In contrast, the function of γδ T cells was markedly enhanced by MMR vaccination, with higher production of TNF and IFN-γ, as well as upregulation of cellular metabolic pathways. In conclusion, we describe a trained immunity program characterized by modulation of γδ T cell function induced by MMR vaccination.