[The pathogenetic validation of antioxidant therapy in the combined treatment of chronic cholecystitis].

Ninety-eight patients with chronic cholecystitis were studied for intensity of lipid peroxidation (LPO), state of the glutathione system (GS), activity of superoxide dismutase (SOD). Revealed in patients at a mature age presenting with exacerbation of chronic cholecystitis were greater extent of LPO, rise in activity of GS enzymes, decline in SOD activity. The main determinant is degree of acuity of the inflammatory process in the gallbladder rather than presence or absence of biliary calculi. The need for and efficacy of antioxidant therapy is shown.