Cell reports · 2025
Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Jiao Han, Jermei Jarne, Liang Xian, van der Zande Hendrik J P, Vrieling Frank, Rumanova Valentina Sophia, Dorscheidt Milan, Wang Anhui, Foppen Ewout, Ignacio Bob, Stenvers Dirk Jan, Liu Tiemin, Bonger Kimberly, Stienstra Rinke, Zhang Zhi, Kalsbeek Andries, Yi Chun-Xia
Аннотация
Time-restricted eating has shown great promise for improving metabolic health in humans with obesity, but its mechanism is still not completely resolved. In this study, we investigated how time-restricted feeding (TRF) affects microglial immunometabolism using Wistar rats. High-fat diet (HFD)-fed animals became obese, but restricting food intake to the active phase reduced fat mass, reinforced the rhythmicity of the microglial transcriptome, and prevented an increase in hypothalamic microglial cell numbers. However, TRF failed to reverse HFD-induced microglial immune dysfunction and metabolic disturbances, including suppressed electron transport chain activity, increased lipid metabolism gene expression, and impaired metabolic flexibility. These findings suggest that obesity-driven microglial immunometabolic reprogramming persists despite TRF-induced weight loss and may contribute to obesogenic memory and weight regain after weight loss induced by dietary interventions.