Journal of surgical oncology · 2015
KPNA2 over-expression is a potential marker of prognosis and therapeutic sensitivity in colorectal cancer patients.
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Takada Takahiro, Tsutsumi Soichi, Takahashi Ryo, Ohsone Katsuya, Tatsuki Hironori, Suto Toshinaga, Kato Toshihide, Fujii Takaaki, Yokobori Takehiko, Kuwano Hiroyuki
Аннотация
BACKGROUND: Karyopherin α 2 (KPNA2) is a member of the Karyopherin α family and has recently been reported to play an important role in tumor progression. The aim of the current study was to elucidate the clinicopathological significance of KPNA2 over-expression in colorectal cancer (CRC).
PATIENTS AND METHODS: KPNA2 expression was evaluated by immunohistochemistry in 122 surgically resected CRC and 13 biopsy specimens obtained at colonoscopy during screening for preoperative hyperthermochemoradiation therapy (HCRT). The association between KPNA2 expression and clinicopathological features and preoperative HCRT efficacy were examined.
RESULTS: The high and low KNPA2 expression groups were comprised of 91 (74.6%) and 31 CRC patients, respectively. A significant association was observed between high expression and lymphatic invasion (P = 0.0245). KPNA2 high expression group had decreased overall survival (P = 0.00374). Multivariate analysis demonstrated high KPNA2 expression was independently associated with poor prognosis. Histological examinations revealed 11 (84.6%) and 2 (15.4%) of cases were KPNA2 positive and negative, respectively. Pathological complete response (pCR) was observed in 9.1% of KPNA2-positive cases and 100% of KPNA2-negative cases.
CONCLUSION: High KPNA2 expression was found to be associated with poor prognosis and resistance to HCRT.
PATIENTS AND METHODS: KPNA2 expression was evaluated by immunohistochemistry in 122 surgically resected CRC and 13 biopsy specimens obtained at colonoscopy during screening for preoperative hyperthermochemoradiation therapy (HCRT). The association between KPNA2 expression and clinicopathological features and preoperative HCRT efficacy were examined.
RESULTS: The high and low KNPA2 expression groups were comprised of 91 (74.6%) and 31 CRC patients, respectively. A significant association was observed between high expression and lymphatic invasion (P = 0.0245). KPNA2 high expression group had decreased overall survival (P = 0.00374). Multivariate analysis demonstrated high KPNA2 expression was independently associated with poor prognosis. Histological examinations revealed 11 (84.6%) and 2 (15.4%) of cases were KPNA2 positive and negative, respectively. Pathological complete response (pCR) was observed in 9.1% of KPNA2-positive cases and 100% of KPNA2-negative cases.
CONCLUSION: High KPNA2 expression was found to be associated with poor prognosis and resistance to HCRT.
Предметные рубрики MeSH
AdultAgedBiomarkers, TumorChemoradiotherapyColorectal NeoplasmsCombined Modality TherapyFemaleGene Expression Regulation, NeoplasticHumansHyperthermia, InducedImmunohistochemistryLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPredictive Value of TestsPrognosisalpha Karyopherins