[Current hypotheses on the development of chronic otitis media with effusion in childhood].

Chronic otitis media with effusion (COME) has a major impact on a child's physical and social development. Socioeconomic risk factors as well as new insights gained with modern laboratory technology and large demographic studies of COME in Central Europe are discussed. In total, 428 articles from the past 8 years on PubMed were reviewed as well as current guidelines of German- and English-speaking countries on COME in children. Problems of many original studies include small patient numbers and bias. In addition, a clear distinction between acute otitis media and COME is often missing. Microbiomic profiles and biofilms seem to play a major role in COME. Established theories on the multifactorial origin of COME are mostly supported by new studies, including new insights into immunological and nutritional risk factors. In addition, the socioeconomic background of a child with COME must not be underestimated, even in first-world countries.