Science (New York, N.Y.) · 2019
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.
СтатьяНаблюдательное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mina Michael J, Kula Tomasz, Leng Yumei, Li Mamie, de Vries Rory D, Knip Mikael, Siljander Heli, Rewers Marian, Choy David F, Wilson Mark S, Larman H Benjamin, Nelson Ashley N, Griffin Diane E, de Swart Rik L, Elledge Stephen J
Аннотация
Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.