eLife · 2021
Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Han Alvin X, Felix Garza Zandra C, Welkers Matthijs Ra, Vigeveno René M, Tran Nhu Duong, Le Thi Quynh Mai, Pham Quang Thai, Dang Dinh Thoang, Tran Thi Ngoc Anh, Ha Manh Tuan, Nguyen Thanh Hung, Le Quoc Thinh, Le Thanh Hai, Hoang Thi Bich Ngoc, Chokephaibulkit Kulkanya, Puthavathana Pilaipan, Nguyen Van Vinh Chau, Nghiem My Ngoc, Nguyen Van Kinh, Dao Tuyet Trinh, Tran Tinh Hien, Wertheim Heiman Fl, Horby Peter W, Fox Annette, van Doorn H Rogier, Eggink Dirk, de Jong Menno D, Russell Colin A
Аннотация
The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on infections in healthy adults based on single timepoint data. Here, we analyzed the within-host evolution of 82 longitudinally sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 viruses between 2007 and 2009. For A/H1N1pdm09 infections during the 2009 pandemic, nonsynonymous minority variants were more prevalent than synonymous ones. For A/H3N2 viruses in young children, early infection was dominated by purifying selection. As these infections progressed, nonsynonymous variants typically increased in frequency even when within-host virus titers decreased. Unlike the short-lived infections of adults where de novo within-host variants are rare, longer infections in young children allow for the maintenance of virus diversity via mutation-selection balance creating potentially important opportunities for within-host virus evolution.