[The Pelger-Huët leukocyte nuclear anomaly: a morphologic, cytochemical, cytogenetic and ultrastructural study of 39 cases (authors' transl)].

Thirtynine of nuclear leukocyte Pelger-Huët anomaly occurring in two Italian families are presented and discussed. The study of the genealogical trees has confirmed that the anomaly is a familial and congenital form, with autosomal dominant inheritance. The incidence of the anomaly in our popolation is 1 to 4,500. In the heterozygous form the anomaly is characterized by decreased segmentation of the nucleus, distinctive nuclear forms and pyknosis of the nuclear chromatin out of proportion of the nuclear area. The results of morphologic, cytochemical, ultrastructural and cytogenetic studies are reported.