DIAPHRAGM FUNCTION IN CHILDREN WITH ACUTE HYPOXEMIC RESPIRATORY FAILURE: THE PROSPECTIVE OBSERVATIONAL COHORT STUDY.

OBJECTIVE

The aim: To find out whether diaphragm dysfunction might lead to unsuccessful weaning from MV.

PATIENTS AND

METHODS

Materials and methods: We provided prospective observational cohort study and included 105 patients and divided them in the study and the control groups. To consider diaphragm function, we check amplitude of its movement and diaphragm thickening fraction (Dtf). The primary outcome was the incidence of successful weaning from MV. The secondary outcomes were changes in diaphragm function parameters.

RESULTS

Results

In the current study, there were found that the incidence of successful weaning from MV was 100% for the day 1 in the control group, while in study group the incidence was significantly lower. Successfully weaned from MV in the study group among children 1 month - 1 year old on day 14 were 20 out 28 patients (71%), in children 1 - 3 years old - 9 out 11 patients (82%), in children 3 - 5 years old - 15 out 15 (100%). However, on day 1 - no one from the study group was weaned (0%), on day 7 - 5 out 28 patients 1 month - 1 year old (18%), 6 out 11 patients (55%) 1 - 3 years old, and 8 out 15 patients (53%) 3 - 5 years old (p<0.05).

CONCLUSION

Conclusions

Diaphragm dysfunction might alter weaning from MV.