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DOI 10.1038/s41598-020-64883-8

Медицинская библиотека · Scientific reports · 2020

Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education.

Jelenkovic Aline, Sund Reijo, Yokoyama Yoshie, Latvala Antti, Sugawara Masumi, Tanaka Mami, Matsumoto Satoko, Freitas Duarte L, Maia José Antonio, Knafo-Noam Ariel, Mankuta David, Abramson Lior, Ji Fuling, Ning Feng, Pang Zengchang, Rebato Esther, Saudino Kimberly J, Cutler Tessa L, Hopper John L, Ullemar Vilhelmina, Almqvist Catarina, Magnusson Patrik K E, Cozen Wendy, Hwang Amie E, Mack Thomas M, Nelson Tracy L, Whitfield Keith E, Sung Joohon, Kim Jina, Lee Jooyeon, Lee Sooji, Llewellyn Clare H, Fisher Abigail, Medda Emanuela, Nisticò Lorenza, Toccaceli Virgilia, Baker Laura A, Tuvblad Catherine, Corley Robin P, Huibregtse Brooke M, Derom Catherine A, Vlietinck Robert F, Loos Ruth J F, Burt S Alexandra, Klump Kelly L, Silberg Judy L, Maes Hermine H, Krueger Robert F, McGue Matt, Pahlen Shandell, Gatz Margaret, Butler David A, Harris Jennifer R, Brandt Ingunn, Nilsen Thomas S, Harden K Paige, Tucker-Drob Elliot M, Franz Carol E, Kremen William S, Lyons Michael J, Lichtenstein Paul, Bartels Meike, Beijsterveldt Catharina E M van, Willemsen Gonneke, Öncel Sevgi Y, Aliev Fazil, Jeong Hoe-Uk, Hur Yoon-Mi, Turkheimer Eric, Boomsma Dorret I, Sørensen Thorkild I A, Kaprio Jaakko, Silventoinen Karri

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Аннотация

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.

Для цитирования: Jelenkovic Aline, Sund Reijo, Yokoyama Yoshie, Latvala Antti, Sugawara Masumi, Tanaka Mami, Matsumoto Satoko, Freitas Duarte L, Maia José Antonio, Knafo-Noam Ariel, Mankuta David, Abramson Lior, Ji Fuling, Ning Feng, Pang Zengchang, Rebato Esther, Saudino Kimberly J, Cutler Tessa L, Hopper John L, Ullemar Vilhelmina, Almqvist Catarina, Magnusson Patrik K E, Cozen Wendy, Hwang Amie E, Mack Thomas M, Nelson Tracy L, Whitfield Keith E, Sung Joohon, Kim Jina, Lee Jooyeon, Lee Sooji, Llewellyn Clare H, Fisher Abigail, Medda Emanuela, Nisticò Lorenza, Toccaceli Virgilia, Baker Laura A, Tuvblad Catherine, Corley Robin P, Huibregtse Brooke M, Derom Catherine A, Vlietinck Robert F, Loos Ruth J F, Burt S Alexandra, Klump Kelly L, Silberg Judy L, Maes Hermine H, Krueger Robert F, McGue Matt, Pahlen Shandell, Gatz Margaret, Butler David A, Harris Jennifer R, Brandt Ingunn, Nilsen Thomas S, Harden K Paige, Tucker-Drob Elliot M, Franz Carol E, Kremen William S, Lyons Michael J, Lichtenstein Paul, Bartels Meike, Beijsterveldt Catharina E M van, Willemsen Gonneke, Öncel Sevgi Y, Aliev Fazil, Jeong Hoe-Uk, Hur Yoon-Mi, Turkheimer Eric, Boomsma Dorret I, Sørensen Thorkild I A, Kaprio Jaakko, Silventoinen Karri. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education.. Scientific reports. 2020. DOI: 10.1038/s41598-020-64883-8.

Предметные рубрики MeSH

AdolescentAdultBody HeightChildChild, PreschoolEnvironmentFemaleGene-Environment InteractionGenetic BackgroundHumansInfantInfant, NewbornMaleParentingParentsQuantitative Trait LociQuantitative Trait, HeritableYoung Adult
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