Microbiology spectrum · 2023
Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Manna Sam, Werren Joel P, Ortika Belinda D, Bellich Barbara, Pell Casey L, Nikolaou Elissavet, Gjuroski Ilche, Lo Stephanie, Hinds Jason, Tundev Odgerel, Dunne Eileen M, Gessner Bradford D, Bentley Stephen D, Russell Fiona M, Mulholland E Kim, Mungun Tuya, von Mollendorf Claire, Licciardi Paul V, Cescutti Paola, Ravenscroft Neil, Hilty Markus, Satzke Catherine
Аннотация
Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as a major virulence factor as well as public health importance as it is the target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 of the >100 known capsular types (serotypes) with higher valency vaccines in development. Here, we have characterized a new pneumococcal serotype, which we have named 33G. We detected serotype 33G in nasopharyngeal swabs (n = 20) from children and adults hospitalized with pneumonia, as well as healthy children in Mongolia. We show that the genetic, serological, and biochemical properties of 33G differ from existing serotypes, satisfying the criteria to be designated as a new serotype. Future studies should focus on the geographical distribution of 33G and any changes in prevalence following vaccine introduction.