Journal of dentistry · 2026
Is erosive tooth wear a truly non-bacterial condition? A scoping review.
СтатьяScoping ReviewНазвание и аннотация: Перевод пока не подготовлен
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González José Alejandro Castro, Brant Camila Freire, Pigossi Suzane Cristina, Wiegand Annette, Sabino-Silva Robinson, Massignan Carla, Zanatta Rayssa Ferreira
Аннотация
OBJECTIVE: This scoping review examined the current knowledge on oral biofilm ecology and erosion-associated dysbiosis, proposing pathways by which the oral microbiome may contribute to erosive tooth wear (ETW).
DATA: The PRISMA-ScR guidelines were followed (OSF platform, doi: 10.17605/OSF.IO/KM4JQ). Primary research articles (in vitro, in situ, or clinical trials) that investigated ETW associated with oral biofilm ecology, erosion-associated dysbiosis, or microbiome pathways were included.
SOURCES: A systematic search of PubMed/MEDLINE, Scopus, Web of Science, Embase, and the Cochrane Library was conducted up to April 2026 using predefined terms.
STUDY SELECTION: A total of 2355 records were identified. After screening, 16 full texts were eligible, and 7 studies were included for data extraction. The included studies were highly heterogeneous in design [including observational (3), randomized (1), and in situ/ex vivo (3) models], outcomes, and biological targets. Two studies evaluated the biofilm´s protective effect against erosive challenge, showing reduced enamel erosion but limited protection of dentin. Two studies assessed bioactive compounds' influence on microbiome, demonstrating reduced bacterial adhesion, altered pellicle structure, and improved erosion protection. Three studies investigated microbial ecology directly with inconsistent findings: one found no significant differences in microbial counts, another reported similar alpha- and beta-diversity but taxon-level differences, and a third showed lower microbial diversity, proteolytic protein degradation, altered gene expression, and metabolic profiles compatible with acid-adapted and proteolytic communities.
CONCLUSIONS: The findings suggest that the oral microbiome may act as an ecological modifier of ETW by influencing biofilm organization, and local metabolic behavior, but current evidence is insufficient to determine whether ETW is truly a non-bacterial condition.
CLINICAL SIGNIFICANCE: The oral microbiome can influence erosive tooth wear, which impacts risk assessment and prevention strategies.
DATA: The PRISMA-ScR guidelines were followed (OSF platform, doi: 10.17605/OSF.IO/KM4JQ). Primary research articles (in vitro, in situ, or clinical trials) that investigated ETW associated with oral biofilm ecology, erosion-associated dysbiosis, or microbiome pathways were included.
SOURCES: A systematic search of PubMed/MEDLINE, Scopus, Web of Science, Embase, and the Cochrane Library was conducted up to April 2026 using predefined terms.
STUDY SELECTION: A total of 2355 records were identified. After screening, 16 full texts were eligible, and 7 studies were included for data extraction. The included studies were highly heterogeneous in design [including observational (3), randomized (1), and in situ/ex vivo (3) models], outcomes, and biological targets. Two studies evaluated the biofilm´s protective effect against erosive challenge, showing reduced enamel erosion but limited protection of dentin. Two studies assessed bioactive compounds' influence on microbiome, demonstrating reduced bacterial adhesion, altered pellicle structure, and improved erosion protection. Three studies investigated microbial ecology directly with inconsistent findings: one found no significant differences in microbial counts, another reported similar alpha- and beta-diversity but taxon-level differences, and a third showed lower microbial diversity, proteolytic protein degradation, altered gene expression, and metabolic profiles compatible with acid-adapted and proteolytic communities.
CONCLUSIONS: The findings suggest that the oral microbiome may act as an ecological modifier of ETW by influencing biofilm organization, and local metabolic behavior, but current evidence is insufficient to determine whether ETW is truly a non-bacterial condition.
CLINICAL SIGNIFICANCE: The oral microbiome can influence erosive tooth wear, which impacts risk assessment and prevention strategies.