Journal of the neurological sciences · 2007
Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study.
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Wada-Isoe Kenji, Kitayama Michio, Nakaso Kazuhiro, Nakashima Kenji
Аннотация
OBJECTIVE: This study examined the diagnostic value of cerebrospinal fluid (CSF) markers and iodine-123 metaiodobenzylguanidine ((123)I-MIBG) cardiac scintigraphy in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD).
METHODS: CSF levels of amyloid beta1-42 (Abeta42) and 181-Thr phosphorylated tau (p-tau) were measured using enzyme linked immunosorbent assay (ELISA) kits. (123)I-MIBG cardiac scintigraphy was performed in patients with AD and DLB, and control (CTL) subjects.
RESULTS: Increased CSF levels of p-tau in AD were found compared to DLB patients and CTL subjects (P<0.01), but there was no significant difference in CSF levels of Abeta42 between AD and DLB patients. The early and delayed heart to mediastinum (H/M) ratios of (123)I-MIBG cardiac scintigraphy were significantly decreased in patients with DLB compared to AD patients and CTL subjects (P<0.01). The receiver operating characteristic (ROC) analysis revealed that the diagnostic value of (123)I-MIBG cardiac scintigraphy was superior to that of CSF markers.
CONCLUSIONS: (123)I-MIBG cardiac scintigraphy may be useful for discriminating between DLB and AD.
METHODS: CSF levels of amyloid beta1-42 (Abeta42) and 181-Thr phosphorylated tau (p-tau) were measured using enzyme linked immunosorbent assay (ELISA) kits. (123)I-MIBG cardiac scintigraphy was performed in patients with AD and DLB, and control (CTL) subjects.
RESULTS: Increased CSF levels of p-tau in AD were found compared to DLB patients and CTL subjects (P<0.01), but there was no significant difference in CSF levels of Abeta42 between AD and DLB patients. The early and delayed heart to mediastinum (H/M) ratios of (123)I-MIBG cardiac scintigraphy were significantly decreased in patients with DLB compared to AD patients and CTL subjects (P<0.01). The receiver operating characteristic (ROC) analysis revealed that the diagnostic value of (123)I-MIBG cardiac scintigraphy was superior to that of CSF markers.
CONCLUSIONS: (123)I-MIBG cardiac scintigraphy may be useful for discriminating between DLB and AD.
Предметные рубрики MeSH
3-IodobenzylguanidineAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainDiagnosis, DifferentialEnzyme-Linked Immunosorbent AssayHumansLewy Body DiseaseMiddle AgedPeptide FragmentsPhosphorylationPredictive Value of TestsROC CurveRadionuclide ImagingRadiopharmaceuticalstau Proteins