Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Asero Riccardo, Tripodi Salvatore, Dondi Arianna, Di Rienzo Businco Andrea, Sfika Ifigenia, Bianchi Annamaria, Candelotti Paolo, Caffarelli Carlo, Povesi Dascola Carlotta, Ricci Giampaolo, Calamelli Elisabetta, Maiello Nunzia, Miraglia Del Giudice Michele, Frediani Tullio, Frediani Simone, Macrì Francesco, Moretti Matteo, Dello Iacono Iride, Patria Maria Francesca, Varin Elena, Peroni Diego, Comberiati Pasquale, Chini Loredana, Moschese Viviana, Lucarelli Sandra, Bernardini Roberto, Pingitore Giuseppe, Pelosi Umberto, Tosca Mariangela, Cirisano Anastasia, Faggian Diego, Plebani Mario, Verga Carmen, Matricardi Paolo Maria, Italian Pediatric Allergy Network (I-PAN)
Аннотация
OBJECTIVES: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas.
METHODS: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA.
RESULTS: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber.
CONCLUSIONS: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age.