Mitochondrion · 2017
Cognitive impairment, clinical severity and MRI changes in MELAS syndrome.
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Kraya Torsten, Neumann Lena, Paelecke-Habermann Yvonne, Deschauer Marcus, Stoevesandt Dietrich, Zierz Stephan, Watzke Stefan
Аннотация
OBJECTIVE: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome.
METHODS: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A>G mutation.
RESULTS: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS.
CONCLUSION: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.
METHODS: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A>G mutation.
RESULTS: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS.
CONCLUSION: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.