Journal of neuroengineering and rehabilitation · 2025
Foot placement coordination is impaired in people with Parkinson's disease.
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Lang Charlotte, Hausdorff Jeffrey M, Bruijn Sjoerd M, Brodie Matthew A, Okubo Yoshiro, Maetzler Walter, van Leeuwen Moira, Singh Navrag B, van Dieen Jaap H, Ravi Deepak K
Аннотация
BACKGROUND: Gait instability is a common and disabling symptom of Parkinson's disease (PD), contributing to frequent falls and reduced quality of life. While clinical balance tests and spatiotemporal gait measures can predict fall risk, they do not fully explain the underlying control mechanisms. In healthy individuals, foot placement is actively adjusted based on an estimate of the Center of Mass (CoM) state to maintain gait stability, known as foot placement control. This estimation relies on the integration of multisensory information, which has been shown to be impaired in PD, potentially disrupting the control of gait stability through foot placement. This study aimed to investigate whether foot placement coordination during overground walking is impaired in people with PD.
METHODS: Fifty people with PD and 51 healthy older adults walked overground for 10 min at self-selected walking speed. Foot placement errors were quantified as the deviation between the actual foot placement and the predicted placement derived from the CoM kinematic state during the preceding swing phase.
RESULTS: Foot placement errors were significantly higher in people with PD than in healthy older adults in both mediolateral (p < 0.05) and anteroposterior directions (p < 0.0001), at both mid-swing and terminal swing. Relative explained variance in mediolateral direction was significantly higher in people with PD compared to healthy older adults (p < 0.005).
CONCLUSION: We provide first evidence of impaired coordination between the CoM and foot placement in PD. Future work should investigate a causal relationship between impaired foot placement control, sensorimotor integration and gait instability.
METHODS: Fifty people with PD and 51 healthy older adults walked overground for 10 min at self-selected walking speed. Foot placement errors were quantified as the deviation between the actual foot placement and the predicted placement derived from the CoM kinematic state during the preceding swing phase.
RESULTS: Foot placement errors were significantly higher in people with PD than in healthy older adults in both mediolateral (p < 0.05) and anteroposterior directions (p < 0.0001), at both mid-swing and terminal swing. Relative explained variance in mediolateral direction was significantly higher in people with PD compared to healthy older adults (p < 0.005).
CONCLUSION: We provide first evidence of impaired coordination between the CoM and foot placement in PD. Future work should investigate a causal relationship between impaired foot placement control, sensorimotor integration and gait instability.