Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis.
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Reimer Cameron J, Jenson Tara E, Tripodis Yorghos, Shiba Koichiro, James Peter, Kirwa Kipruto, Heckbert Susan R, Hirsch Jana A, Besser Lilah, Hughes Timothy, Kaufman Joel D, Coull Brent A, Pescador Jimenez Marcia
Аннотация
INTRODUCTION: There is a critical need to identify risk factors of Alzheimer's disease and related dementias (ADRD).
METHODS: We included 1227 participants (mean age [standard deviation]: 74.1 [7.9] years) from the Multi-Ethnic Study of Atherosclerosis with brain MRI scans. We investigated joint associations of 13 natural, social, and built-environment exposures with gray matter volume (GMV) (n = 1219), white matter fractional anisotropy (WM FA) (n = 1102), and white matter hyperintensity volume (n = 1210) using weighted quantile sum regression.
RESULTS: A one-decile increase in all harmful exposures was associated with lower GMV and WM FA; however, associations were null when adjusting for study site.
DISCUSSION: Examining the impact of many environmental factors simultaneously may provide insight into important modifiable risk factors for ADRD, capturing concomitant exposures as they are experienced.
METHODS: We included 1227 participants (mean age [standard deviation]: 74.1 [7.9] years) from the Multi-Ethnic Study of Atherosclerosis with brain MRI scans. We investigated joint associations of 13 natural, social, and built-environment exposures with gray matter volume (GMV) (n = 1219), white matter fractional anisotropy (WM FA) (n = 1102), and white matter hyperintensity volume (n = 1210) using weighted quantile sum regression.
RESULTS: A one-decile increase in all harmful exposures was associated with lower GMV and WM FA; however, associations were null when adjusting for study site.
DISCUSSION: Examining the impact of many environmental factors simultaneously may provide insight into important modifiable risk factors for ADRD, capturing concomitant exposures as they are experienced.