Clinical characteristics and etiologies of bronchiectasis in Korean children: A multicenter retrospective study.
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Lee Eun, Shim Jung Yeon, Kim Hyung Young, Suh Dong In, Choi Yun Jung, Han Man Young, Baek Kyung Suk, Kwon Ji-Won, Cho Joongbum, Jung Minyoung, Kim Young Suh, Sol In Suk, Kim Bong-Seong, Chung Eun Hee, Lee Sooyoung, Jeong Kyunguk, Jang Yoon Young, Jang Gwang Cheon, Hyun Myung Chul, Yang Hyeon-Jong, Shin Meeyong, Kim Jin Tack, Kim Ja Hyeong, Hwang Yoon Ha, Ahn Ji Young, Seo Ju-Hee, Jung Jin A, Kim Hwan Soo, Oh Moo Young, Park Yang, Lee Mi-Hee, Lee So-Yeon, Jung Sungsu, Hong Soo-Jong, Ahn Young Min, on the behalf of Pediatric Respiratory and Diseases Study Party
Аннотация
METHODS: We performed a retrospective review of the medical records for children diagnosed with bronchiectasis between 2000 and 2017 at 28 secondary or tertiary hospitals in South Korea.
RESULTS: A total of 387 cases were enrolled. The mean age at diagnosis was 9.2 ± 5.1 years and 53.5% of the patients were boys. The most common underlying cause of bronchiectasis was preexisting respiratory infection (55.3%), post-infectious bronchiolitis obliterans (14.3%), pulmonary tuberculosis (12.3%), and heart diseases (5.6%). Common initial presenting symptoms included chronic cough (68.0%), recurrent pneumonia (36.4%), fever (31.1%), and dyspnea (19.7%). The most predominantly involved lesions were left lower lobe (53.9%), right lower lobe (47.1%) and right middle lobe (40.2%). No significant difference was observed in the distribution of these involved lesions by etiology. The forced expiratory volume in 1 s (FEV1) levels were lowest in cases with interstitial lung disease-associated bronchiectasis, followed by those with recurrent aspiration and primary immunodeficiency.
CONCLUSIONS: Bronchiectasis should be strongly considered in children with chronic cough and recurrent pneumonia. Long-term follow-up studies on pediatric bronchiectasis are needed to further clarify the prognosis and reduce the disease burden in these patients.