Neurocase · 2012
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?
Клинический случайСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Sitek Emilia J, Narozanska Ewa, Barczak Anna, Jasinska-Myga Barbara, Harciarek Michał, Chodakowska-Zebrowska Małgorzata, Kubiak Małgorzata, Wieczorek Dariusz, Konieczna Seweryna, Rademakers Rosa, Baker Matt, Berdynski Mariusz, Brockhuis Bogna, Barcikowska Maria, Zekanowski Cezary, Heilman Kenneth M, Wszolek Zbigniew K, Slawek Jarosław
Аннотация
OBJECTIVES: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.
METHODS: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.
RESULTS: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.
CONCLUSION: Agraphia associated with FTDP-17 is very heterogeneous.
METHODS: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.
RESULTS: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.
CONCLUSION: Agraphia associated with FTDP-17 is very heterogeneous.