Enhanced nursing and ganciclovir improve outcomes in paediatric Epstein-Barr Virus infectious mononucleosis: A Randomised Control Trial.

OBJECTIVE

To investigate the impact of high-quality nursing interventions and ganciclovir on paediatric Epstein-Barr virus infectious mononucleosis.

METHODS

The randomised controlled trial was conducted from March to August 2021 at the Departments of Paediatrics, Maternal and Child Health Hospital, Tangshan, China, and comprised paediatric patients diagnosed with Epstein-Barr virus infectious mononucleosis. The patients were randomised into intervention group A receiving high-quality nursing interventions and ganciclovir, and control group B receiving routine standard care. Primary outcomes included symptom reduction and laboratory markers, while secondary outcomes included length of hospital stay, time to resolution of symptoms, adverse events, and patient-reported outcomes. Data was analysed using SPSS 28.

RESULTS

Of the 100 subjects, 50(50%) were in group A; 31(62%) boys and 19(38%) girls with mean age 9.15±1.45 years. There were 50(50%) patients in group B; 30(60%) boys and 20(40%) girls with mean age 9.15±1.34 years. Group A demonstrated improvements in outcomes compared to group B (p<0.05).

CONCLUSIONS

Ganciclovir and good nursing improved paediatric Epstein-Barr virus infectious mononucleosis treatment.