The British journal of dermatology · 2004
Tobacco smoke is phototoxic.
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Placzek M, Kerkmann U, Bell S, Koepke P, Przybilla B
Аннотация
BACKGROUND: Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing.
OBJECTIVES: To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke.
METHODS: A photohaemolysis test was used, in which human erythrocytes were incubated with cigarette smoke condensate, followed by UV irradiation and measurement of exposure-dependent haemolysis.
RESULTS: Cigarette smoke condensate was clearly phototoxic. Photohaemolysis depended on the concentration of the condensate and UV dose and was more pronounced after exposure to UVA-rich than UVB-rich radiation.
CONCLUSIONS: Phototoxicity may be a mechanism by which cigarette smoking causes premature skin ageing. An enhancing effect on photocarcinogenesis has also to be considered.
OBJECTIVES: To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke.
METHODS: A photohaemolysis test was used, in which human erythrocytes were incubated with cigarette smoke condensate, followed by UV irradiation and measurement of exposure-dependent haemolysis.
RESULTS: Cigarette smoke condensate was clearly phototoxic. Photohaemolysis depended on the concentration of the condensate and UV dose and was more pronounced after exposure to UVA-rich than UVB-rich radiation.
CONCLUSIONS: Phototoxicity may be a mechanism by which cigarette smoking causes premature skin ageing. An enhancing effect on photocarcinogenesis has also to be considered.