Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2010
Determining the incidence of aspergillosis after liver transplant.
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Badiee Parisa, Alborzi Abdolvahab, Malekhosseini Seyed Ali, Nikeghbalian Saman, Shakiba Elaheh
Аннотация
OBJECTIVES: Aspergillus has become an increasingly frequent cause of life-threatening opportunistic infections in liver transplant recipients. This study seeks to determine the incidence of invasive aspergillosis in liver transplant recipients using routine and molecular methods in a teaching hospital in Shiraz, the unique center for liver transplant in Iran.
MATERIALS AND METHODS: Four hundred eight recipients who underwent liver transplant were followed for Aspergillus infections by microscopic examination, culture, and nested polymerase chain reaction. Blood samples were cultured by bedside inoculation to BACTEC medium.
RESULTS: The female-to-male ratio was 151:257 (mean age, 29.6 years; mean hospitalization, 26 days). Sensitivity and specificity of the nested polymerase chain reaction was 92.8% and 94%. Aspergillosis was detected in 19 recipients (4.6%) by routine and molecular method (4 proven, 10 probable, and 5 possible) of whom 12 recipients died (63.2%).
CONCLUSIONS: This study found the incidence rate of invasive aspergillosis as an uncommon complication of liver transplant recipient cases but associated with poor outcomes. The rate is consistent with those reported in previous studies, but molecular assay that is more-sensitive and specific was used in the present study.
MATERIALS AND METHODS: Four hundred eight recipients who underwent liver transplant were followed for Aspergillus infections by microscopic examination, culture, and nested polymerase chain reaction. Blood samples were cultured by bedside inoculation to BACTEC medium.
RESULTS: The female-to-male ratio was 151:257 (mean age, 29.6 years; mean hospitalization, 26 days). Sensitivity and specificity of the nested polymerase chain reaction was 92.8% and 94%. Aspergillosis was detected in 19 recipients (4.6%) by routine and molecular method (4 proven, 10 probable, and 5 possible) of whom 12 recipients died (63.2%).
CONCLUSIONS: This study found the incidence rate of invasive aspergillosis as an uncommon complication of liver transplant recipient cases but associated with poor outcomes. The rate is consistent with those reported in previous studies, but molecular assay that is more-sensitive and specific was used in the present study.
Предметные рубрики MeSH
AdolescentAdultAntifungal AgentsAspergillusChildChild, PreschoolDNA, FungalDrug Administration ScheduleDrug Therapy, CombinationFemaleHospitals, TeachingHumansImmunosuppressive AgentsIncidenceInfantInvasive Pulmonary AspergillosisIranLength of StayLiver TransplantationMaleMiddle AgedPolymerase Chain ReactionRibotypingTime FactorsTreatment OutcomeYoung Adult