THE VALUE OF QUANTITY OF STREPTOCOCCI ON THE NASAL AND OROPHARYNGEAL MUCOSA ON THE FORMATION OF THE CELLULAR IMMUNITY IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS.

The article presents the results of a comparative analysis of the cellular level of the immune response of children with mononucleosis in different periods of the disease of IM in children with different degrees of dissemination by streptococcus from their nasal and oropharyngeal mucosa. To achieve the goal, 60 children aged from three to seven years old with patients with infectious mononucleosis were examined, who were treated at the Regional Children's Infectious Clinical Hospital of Kharkiv, Ukraine. In 30 children (the first group), Streptococcus pyogenes was isolated in concentrations of 10-5 and higher during bacteriological examination of the nasal and oropharyngeal mucosa. 30 (second group) - 10-4 degrees or less. It has been established that the presence of streptococcus concentrations of 10-5 and higher in the naso-pharyngeal mucosa of patients with mononucleosis leads to the development of partial cell immunodeficiency which persists until the period of early convalescence. The presence of streptococcus in a concentration of more than 10-5 on the mucous membrane of the nasopharynx in patients with IM leads not only to changes in the immune response of children, but also affects the severity and duration of clinical manifestations of the disease. In our opinion, pathogenic flora can also contribute to the formation of adverse outcomes of the disease this issue requires further study. The obtained results must be taken into account in treating patients both in the acute period and during the stages of convalescence.