Allergologia et immunopathologia · 2015
Study of SH2D1A gene mutation in paediatric patients with B-cell lymphoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Koochakzadeh L, Hosseinverdi S, Hedayat M, Farahani F, Tofighi A, Eghbali M, Bidoki A Z, Izadyar M, Rahiminejad M S, Ramyar A, Aghamohammadi A, Rezaei N
Аннотация
BACKGROUND: X-linked lymphoproliferative disease (XLP) is an often fatal inherited immunodeficiency disorder characterised by fulminant infectious mononucleosis, acquired haemophagocytic lymphohistiocytosis, dysgammaglobulinaemia and malignant lymphoma. Given the paucity of data on the genetic stratification of XLP gene mutations in paediatric patients diagnosed with B-cell lymphoma, we sought to determine the existence of such association in the present study.
METHODS: We studied 20 male subjects diagnosed with non-Hodgkin B-cell lymphoma.
RESULTS: Eleven patients had laboratory evidence of EBV infection by serology and quantitative PCR. The SH2D1A gene analysis was negative in all patients.
CONCLUSIONS: This is the first study to analyse the SH2D1A gene mutations in Iranian paediatric patients diagnosed with lymphoma. Although we could not demonstrate such an association in our cohort of patients, larger, multi-centre studies are required to extend and confirm our early findings.
METHODS: We studied 20 male subjects diagnosed with non-Hodgkin B-cell lymphoma.
RESULTS: Eleven patients had laboratory evidence of EBV infection by serology and quantitative PCR. The SH2D1A gene analysis was negative in all patients.
CONCLUSIONS: This is the first study to analyse the SH2D1A gene mutations in Iranian paediatric patients diagnosed with lymphoma. Although we could not demonstrate such an association in our cohort of patients, larger, multi-centre studies are required to extend and confirm our early findings.
Предметные рубрики MeSH
AdolescentB-LymphocytesChildChild, PreschoolDNA Mutational AnalysisEpstein-Barr Virus InfectionsGenetic Association StudiesGenetic Predisposition to DiseaseHerpesvirus 4, HumanHumansIntracellular Signaling Peptides and ProteinsIranLymphoma, Non-HodgkinLymphoproliferative DisordersMaleMutationPolymorphism, GeneticSignaling Lymphocytic Activation Molecule Associated ProteinYoung Adult