Journal of dentistry · 2026
Effectiveness of silver diamine fluoride and fluoride varnish in arresting caries lesions in permanent molars: A randomized controlled trial.
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Sabino E Andrade Rafaela, Piovesan Érica Torres de Almeida, Queiroz Ingrid Quaresma Diniz de, Azevedo Tatiana Degani Paes Leme, Costa Vanessa Polina Pereira, Bezerra Ana Cristina Barreto
Аннотация
OBJECTIVES: This study aimed to compare the efficacy of 38 % silver diamine fluoride (SDF) and 5 % fluoride varnish (FV) in arresting caries lesions in first permanent molars, considering their eruption status as a secondary clinical factor.
METHODS: A randomized, controlled, blinded clinical trial was conducted with 165 children (6-12 years). A total of 660 first permanent molars were assessed; 139 teeth with ICDAS scores 1 or 2 were included for analysis. Participants were assigned via cluster randomization (school-level) to G1 (38 % SDF + KI) or G2 (5 % FV). Follow-up assessments were conducted after six months to evaluate caries arrest using ICDAS criteria.
RESULTS: After six months, 88.1 % of teeth in the SDF group (G1) reached an ICDAS score of 0, compared to 65.6 % in the FV group (G2) (p < 0.001). The stage of molar eruption did not significantly influence the outcomes in either group (p = 0.99). Both treatments significantly reduced ICDAS scores from baseline (p < 0.001), but SDF demonstrated superior effectiveness.
CONCLUSIONS: 38 % SDF is more effective than 5 % fluoride varnish in arresting early-stage occlusal caries lesions in first permanent molars, regardless of the eruption stage.
CLINICAL SIGNIFICANCE: SDF offers a highly effective, non-invasive, single-session alternative for managing early caries in permanent molars. Its efficacy is maintained even in partially erupted teeth, making it a practical tool for public health programs and pediatric clinical practice.
METHODS: A randomized, controlled, blinded clinical trial was conducted with 165 children (6-12 years). A total of 660 first permanent molars were assessed; 139 teeth with ICDAS scores 1 or 2 were included for analysis. Participants were assigned via cluster randomization (school-level) to G1 (38 % SDF + KI) or G2 (5 % FV). Follow-up assessments were conducted after six months to evaluate caries arrest using ICDAS criteria.
RESULTS: After six months, 88.1 % of teeth in the SDF group (G1) reached an ICDAS score of 0, compared to 65.6 % in the FV group (G2) (p < 0.001). The stage of molar eruption did not significantly influence the outcomes in either group (p = 0.99). Both treatments significantly reduced ICDAS scores from baseline (p < 0.001), but SDF demonstrated superior effectiveness.
CONCLUSIONS: 38 % SDF is more effective than 5 % fluoride varnish in arresting early-stage occlusal caries lesions in first permanent molars, regardless of the eruption stage.
CLINICAL SIGNIFICANCE: SDF offers a highly effective, non-invasive, single-session alternative for managing early caries in permanent molars. Its efficacy is maintained even in partially erupted teeth, making it a practical tool for public health programs and pediatric clinical practice.