Head & neck · 2026
Significance of Preoperative Imaging-Detected Extranodal Extension in Pathological Extranodal Extension-Positive Head and Neck Squamous Cell Carcinoma Treated With Postoperative Chemoradiotherapy.
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Hoshi Yuta, Kuno Hirofumi, Sakashita Shingo, Hiyama Takashi, Onaga Ryutaro, Okano Susumu, Enokida Tomohiro, Fujisawa Takao, Tanaka Nobukazu, Kishida Takuma, Kuboki Ryo, Kanemoto Kai, Ishii Genichiro, Asakage Takahiro, Tahara Makoto
Аннотация
BACKGROUND: The Head and Neck Cancer International Group (HNCIG) recently proposed standardized classifications for imaging-detected extranodal extension (iENE) and pathological ENE (pENE). We evaluated the prognostic value of iENE in pENE-positive head and neck squamous cell carcinoma (HNSCC) treated with postoperative chemoradiotherapy (CRT).
METHODS: Patients with pENE-positive HNSCC who underwent postoperative CRT were retrospectively analyzed. iENE and pENE were re-classified using HNCIG criteria. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox proportional hazards models.
RESULTS: Ninety-two patients were included. iENE grades 2-3 were associated with significantly worse outcomes than grades 0-1 (3-year RFS: 68.5% vs. 31.5%, log-rank p = 0.0002; 3-year OS: 85.0% vs. 63.2%, log-rank p = 0.02). In multivariable analysis, iENE was the only independent prognostic factor for RFS and OS.
CONCLUSION: Preoperative iENE is a prognostic factor in pENE-positive HNSCC after postoperative CRT, with grades 2-3 identifying a very high-risk population.
METHODS: Patients with pENE-positive HNSCC who underwent postoperative CRT were retrospectively analyzed. iENE and pENE were re-classified using HNCIG criteria. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox proportional hazards models.
RESULTS: Ninety-two patients were included. iENE grades 2-3 were associated with significantly worse outcomes than grades 0-1 (3-year RFS: 68.5% vs. 31.5%, log-rank p = 0.0002; 3-year OS: 85.0% vs. 63.2%, log-rank p = 0.02). In multivariable analysis, iENE was the only independent prognostic factor for RFS and OS.
CONCLUSION: Preoperative iENE is a prognostic factor in pENE-positive HNSCC after postoperative CRT, with grades 2-3 identifying a very high-risk population.
Предметные рубрики MeSH
HumansRetrospective StudiesFemaleHead and Neck NeoplasmsExtranodal ExtensionMalePrognosisMiddle AgedSquamous Cell Carcinoma of Head and NeckAgedCarcinoma, Squamous CellChemoradiotherapyDisease-Free SurvivalProportional Hazards ModelsAdultPostoperative CareKaplan-Meier EstimatePreoperative CareNeoplasm Staging