Noninvasive reduction of neural rigidity alters autistic behaviors in humans.

Autistic behaviors correlate with reductions in specific brain-state transitions in global neural dynamics, implying that the mitigation of such rigid brain dynamics may alter autistic traits. To examine this possibility, we investigated longitudinal behavioral effects of state-dependent transcranial magnetic stimulation (TMS) in autistic adults. We found that excitatory TMS over the right parietal lobule decreased neural rigidity, which commensurately reduced social and nonsocial autistic behaviors. Specifically, TMS-induced neural flexibility immediately decreased cognitive inflexibility and slowly reduced overstable perception and atypical nonverbal communication. In particular, perceptual overstability was reduced after TMS-induced neural flexibility strengthened the coupling between the frontoparietal and visual networks, whereas atypical nonverbal communication became less explicit when the neural flexibility enhanced the coupling between the frontoparietal, default mode and salience networks. These results indicate that alteration of neural rigidity could change multiple autistic traits.