BMC genomics · 2025
Genomic characterization of Staphylococcus epidermidis Se252 isolated from the rhizosphere of a Brazilian endemic plant.
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Sanchez Angélica Bianchini, Lemes Camila Gracyelle de Carvalho, Cordeiro Isabella Ferreira, Caneschi Washington Luiz, Barbosa Érica Felestrino, de Paula Camila Henriques, da Silva Ana Karla, Ribeiro Dilson Fagundes, de Matos Rosilene Cristina, de Matos Jéssica Pereira, Rocha Lorrana Cachuite Mendes, Damasceno Maria Rosilene Alves, Garcia Camila Carrião Machado, Setubal João Carlos, de Mello Varani Alessandro, Almeida Nalvo Franco, Moreira Leandro Marcio
Аннотация
BACKGROUND: Staphylococcus epidermidis (Se) is commonly regarded as a commensal organism; however, under specific conditions, it may act as an opportunistic pathogen. Here, we report the whole-genome sequencing and comparative genomic analysis of Se strain 252 (Se252), isolated from the rhizosphere of an endemic Brazilian plant. RESULTS: Se252 exhibits a unique repertoire of genes associated with environmental adaptation and virulence. These include two putative Type VII secretion system (T7SS) effectors and thirteen proteins involved in adhesion, toxin production, and immune evasion—among them, IsaB, which has not been previously reported in Se. Gene family expansions were observed in loci related to phenol-soluble modulins (PSMs), TLpps, LPXTG-motif proteins, nonribosomal peptide synthetases (NRPS), and siderophore biosynthesis (staphylopine, staphyloferrin), as well as quorum-sensing autoinducing peptides. In contrast, Se252 harbors relatively few antibiotic resistance genes. CONCLUSIONS: The genomic profile of Se252 reflects adaptations to a plant-associated environment, yet harbors multiple features potentially enhancing human pathogenicity. These findings highlight the relevance of environmental Se lineages as possible reservoirs of virulence traits with implications for public health.