Journal of paediatrics and child health · 2013
Patterns of sensitisation to common food and inhalant allergens and allergic symptoms in pre-school children.
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Kim Hyeong Yun, Shin Youn Ho, Yum Hye Yung, Jee Hye Mi, Jang Sun Jung, Yoon Jung Won, Han Man Yong
Аннотация
AIM: Sensitisation to allergens and allergy symptoms depends on age, but this relationship is poorly understood. We therefore investigated the effect of age on allergen sensitisation and allergy symptoms in pre-school children.
METHODS: A cross-sectional study was conducted on 629 Korean children (age 3 to 6 years). Current allergic symptoms were assessed by the Korean version of the International Study of Asthma and Allergies in Childhood questionnaire that was adapted for pre-school children. Sensitisation to five airborne and three food allergens was evaluated by a skin prick test. χ(2) test was used to analyse differences in age trend. Multiple logistic regression analysis was performed to obtain the adjusted odds ratios (aOR) for allergic disease.
RESULTS: As age increased, the prevalence of current rhinitis (P < 0.001), the sensitisation to pollen allergens (P < 0.001) and polysensitised children (P = 0.002) increased, but the prevalence of current asthma (P = 0.010) and the sensitisation to food allergens (P = 0.009) decreased. There was no effect of age on the prevalence of current eczema (P = 0.685), monosensitised children (P = 0.282) and atopy (P = 0.160). The agreement between sensitisation to dust mites and atopy increased with age, and was 93% at age 6 years (P = 0.05). The polysensitisation (aOR = 3.0 (95% CI, 1.4-5.0), P < 0.005) and the presence of eczema in the first 2 years of life (aOR = 4.1 (95% CI, 2.2-7.6), P < 0.001) were significant independent risk factors for current rhinoconjunctivitis.
CONCLUSION: The type and number of allergen sensitisations and allergic symptoms changed from age 3 to 6 years. Careful follow-up of changes in sensitisation patterns may provide a better understanding of the pathogenesis of the allergic march.
METHODS: A cross-sectional study was conducted on 629 Korean children (age 3 to 6 years). Current allergic symptoms were assessed by the Korean version of the International Study of Asthma and Allergies in Childhood questionnaire that was adapted for pre-school children. Sensitisation to five airborne and three food allergens was evaluated by a skin prick test. χ(2) test was used to analyse differences in age trend. Multiple logistic regression analysis was performed to obtain the adjusted odds ratios (aOR) for allergic disease.
RESULTS: As age increased, the prevalence of current rhinitis (P < 0.001), the sensitisation to pollen allergens (P < 0.001) and polysensitised children (P = 0.002) increased, but the prevalence of current asthma (P = 0.010) and the sensitisation to food allergens (P = 0.009) decreased. There was no effect of age on the prevalence of current eczema (P = 0.685), monosensitised children (P = 0.282) and atopy (P = 0.160). The agreement between sensitisation to dust mites and atopy increased with age, and was 93% at age 6 years (P = 0.05). The polysensitisation (aOR = 3.0 (95% CI, 1.4-5.0), P < 0.005) and the presence of eczema in the first 2 years of life (aOR = 4.1 (95% CI, 2.2-7.6), P < 0.001) were significant independent risk factors for current rhinoconjunctivitis.
CONCLUSION: The type and number of allergen sensitisations and allergic symptoms changed from age 3 to 6 years. Careful follow-up of changes in sensitisation patterns may provide a better understanding of the pathogenesis of the allergic march.