Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Martínez-Ciarpaglini Carolina, Barros Rita, Caballero Carmelo, Boggino Hugo, Alarcón-Molero Lorena, Peleteiro Bárbara, Ruiz-García Erika, Fernandez-Figueroa Edith, Herrera-Goepfert Roberto, Díaz-Romero Consuelo, Ferreira Rui, Groen-van Schooten Tessa S, Gauna Cinthia, Pereira Rita, Cantero Daniel, Lezcano Horacio, Esteso Federico, O Connor Juan, Riquelme Arnoldo, Owen Gareth I, Garrido Marcelo, Roa Juan Carlos, Ruiz-Pace Fiorella, Vivancos Ana, Diez-García Marc, Alsina Maria, Matito Judit, Martin Agatha, Gómez Marina, Castillo Ester, Vila Maria, Santos-Antunes João, Costa Andreia, Lordick Florian, Farrés Judith, Palomar-De Lucas Brenda, Cabeza-Segura Manuel, Villagrasa Rosanna, Jimenez-Martí Elena, Miralles-Marco Ana, Dienstmann Rodrigo, Derks Sarah, Figueiredo Ceu, Cervantes Andrés, Carneiro Fátima, Fleitas-Kanonnikoff Tania
Аннотация
MATERIAL AND METHODS: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries. Formalin-fixed paraffin-embedded primary tumour endoscopic biopsy samples were collected and submitted for central morphological and immunohistochemical characterization and TP53 molecular assessment and Helicobacter pylori infection.
RESULTS: A total of 259 patients were included in the study: 137 (53%) from LATAM and 122 (47%) from Europe. Significant biological differences were detected between European and LATAM patients. Low representation of chromosomal instability (CIN) and HER2 positive cases were found in LATAM. MUC6 and PD-L1 were more frequently overexpressed in European cases, showing a significant correlation across the entire study population, with this association being especially pronounced in MMRdeficient cases. Both TP53 mutation by next-generation sequencing and p53 immunohistochemical aberrant pattern were linked with features associated with chromosomal instability. No regional differences were observed in H. pylori prevalence or abundance, indicating that the afore mentioned variations cannot be attributed to this factor.
CONCLUSION: Our findings underscore a need for region-specific approaches in gastroesophageal cancer diagnosis and treatment. MUC6 emerges as a putative immune regulator that needs further investigation. Research tailored to the unique biological profiles in different global regions is crucial to effectively address the observed disparities.