AJNR. American journal of neuroradiology · 2009
Diffuse white matter damage is absent in neuromyelitis optica.
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Aboul-Enein F, Krssák M, Höftberger R, Prayer D, Kristoferitsch W
Аннотация
BACKGROUND AND PURPOSE: Neuromyelitis optica (NMO) is an idiopathic mostly relapsing inflammatory disease with attacks on the optic nerves and spinal cord. Whether NMO is a separate disease or a subtype of classic multiple sclerosis (MS) is unclear. Clinically, CSF and MR imaging parameters and histopathologic data suggest that the normal-appearing white matter (NAWM) may be affected in MS but not in patients with NMO. Therefore, we hypothesized that the NAWM in NMO is normal.
MATERIAL AND METHODS: We studied prospectively 8 patients with clinically definitive NMO or remitting longitudinal extensive transverse myelitis (LETM) and 8 healthy controls. Ratios of N-acetylaspartate to creatine (Cr) and choline to Cr and the absolute concentrations of the metabolites were measured by chemical shift imaging with a (1)H-MR spectroscopy operating at 3T. All patients with clinically definitive NMO and LETM were found to be positive for NMO-immunoglobin G with a commercially available test.
RESULTS: The metabolic pattern of the NAWM of patients with NMO showed no difference compared with age- and sex-matched healthy controls.
CONCLUSIONS: Diffuse white matter damage is absent in NMO.
MATERIAL AND METHODS: We studied prospectively 8 patients with clinically definitive NMO or remitting longitudinal extensive transverse myelitis (LETM) and 8 healthy controls. Ratios of N-acetylaspartate to creatine (Cr) and choline to Cr and the absolute concentrations of the metabolites were measured by chemical shift imaging with a (1)H-MR spectroscopy operating at 3T. All patients with clinically definitive NMO and LETM were found to be positive for NMO-immunoglobin G with a commercially available test.
RESULTS: The metabolic pattern of the NAWM of patients with NMO showed no difference compared with age- and sex-matched healthy controls.
CONCLUSIONS: Diffuse white matter damage is absent in NMO.