Neurobiology of aging · 2025
Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults.
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
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Sapkota Shraddha, Maillard Pauline, Fletcher Evan M, Harvey Danielle J, Olichney John M, Farias Sarah Tomaszewski, Gilsanz Paola, Mungas Dan, Whitmer Rachel A, DeCarli Charles
Аннотация
INTRODUCTION: Differences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We identifieded lifestyle risk factors that best discriminat memory trajectories in older adults without cognitive impairment.
METHOD: The study included 523 older adults from the University of California, Davis-Alzheimer's disease Research Center and 1097 from the Kaiser Healthy-Aging and Diverse Life-Experiences Study. Age, sex, and 13 lifestyle risk factors were used to discriminate latent class memory trajectories in African Americans, Hispanics, and Whites. Structural equation modeling and machine learning methods were applied.
RESULTS: In both cohorts, three patterns of memory trajectories were identified. While there was overlap between risk factors discriminating high and low memory patterns for everyone, we also identified key differences in the top predictors across groups in both cohorts.
DISCUSSION: Identifying relative importance of lifestyle risk factors will promote early identification of adults with differential memory performance across and within racial and ethnic groups.
METHOD: The study included 523 older adults from the University of California, Davis-Alzheimer's disease Research Center and 1097 from the Kaiser Healthy-Aging and Diverse Life-Experiences Study. Age, sex, and 13 lifestyle risk factors were used to discriminate latent class memory trajectories in African Americans, Hispanics, and Whites. Structural equation modeling and machine learning methods were applied.
RESULTS: In both cohorts, three patterns of memory trajectories were identified. While there was overlap between risk factors discriminating high and low memory patterns for everyone, we also identified key differences in the top predictors across groups in both cohorts.
DISCUSSION: Identifying relative importance of lifestyle risk factors will promote early identification of adults with differential memory performance across and within racial and ethnic groups.