Sleep medicine · 2025
Nocturnal oximetry profile in hospitalized children with asthma exacerbation upon hospital discharge.
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Panagiotou Panagiota, Chantzaras Anastasios-Panagiotis, Sergentanis Theodoros N, Moudaki Aggeliki, Michos Athanasios, Kanaka-Gantenbein Christina, Kaditis Athanasios G
Аннотация
BACKGROUND: Asthma exacerbation is a cause of morbidity and mortality in the pediatric population. In guidelines there is no consensus regarding discharge criteria post exacerbation. Moreover, sleep has a known impact on gas exchange, which might be clinically relevant in patients with obstructive lung disease. Therefore, the aim of this study was to investigate the nocturnal oximetry profile in hospitalized children with asthma exacerbation, pre-discharge.
MATERIALS AND METHODS: Nocturnal oximetry recordings of children with asthma admitted in Aghia Sofia Children's Hospital between December 2020 and April 2024 were reviewed. In this cross-sectional study we compared them with recordings of children with Sleep Disordered Breathing (SDB) and controls. Night-time basal SpO2, Oxygen Desaturation Index3 (ODI3), as well as % of time spent <95 % were compared. The Kruskal-Wallis test was employed to evaluate heterogeneity, followed by Mann-Whitney-Wilcoxon test for pairwise comparisons between the groups.
RESULTS: Asthmatic patients (n = 13) had lower basal SpO2 in comparison with control (n = 21) and SDB group (N = 37) (SpO2 93.7 % versus 96.4 % and 96.7 % respectively, p < 0.0001). They spent more time in SpO2< 95 % and had similar ODI3 with the two other groups (p < 0.001 and p < 0.001 for asthma versus SDB and asthma versus control group respectively). Moreover, in patients with asthma a higher spot SpO2 was documented during the day, versus night-time basal SpO2.
CONCLUSION: This study highlights that clinical improvement precedes SpO2 improvement in asthmatic patients. A clinical review 48 h post-discharge is advisable. Nocturnal basal SpO2 is lower than daytime spot SpO2, which should be taken under consideration in implementation of guidelines.
MATERIALS AND METHODS: Nocturnal oximetry recordings of children with asthma admitted in Aghia Sofia Children's Hospital between December 2020 and April 2024 were reviewed. In this cross-sectional study we compared them with recordings of children with Sleep Disordered Breathing (SDB) and controls. Night-time basal SpO2, Oxygen Desaturation Index3 (ODI3), as well as % of time spent <95 % were compared. The Kruskal-Wallis test was employed to evaluate heterogeneity, followed by Mann-Whitney-Wilcoxon test for pairwise comparisons between the groups.
RESULTS: Asthmatic patients (n = 13) had lower basal SpO2 in comparison with control (n = 21) and SDB group (N = 37) (SpO2 93.7 % versus 96.4 % and 96.7 % respectively, p < 0.0001). They spent more time in SpO2< 95 % and had similar ODI3 with the two other groups (p < 0.001 and p < 0.001 for asthma versus SDB and asthma versus control group respectively). Moreover, in patients with asthma a higher spot SpO2 was documented during the day, versus night-time basal SpO2.
CONCLUSION: This study highlights that clinical improvement precedes SpO2 improvement in asthmatic patients. A clinical review 48 h post-discharge is advisable. Nocturnal basal SpO2 is lower than daytime spot SpO2, which should be taken under consideration in implementation of guidelines.