Bibliometric analysis of the pathogenesis of Parkinson's Disease.

BACKGROUND

This article provides an overview of research advancements and emerging trends in the pathogenesis of Parkinson's disease (PD) from 2015 to 2024, offering a reference for researchers in this field.

METHODS

A literature search was conducted using the Web of Science Core Collection (WoSCC) with the query terms: ((TS = (Parkinson's disease)) OR TS = (Parkinson disease)) AND TS = (pathogenesis). Bibliometric analysis and visualization of the search results were performed using CiteSpace and VOSviewer.

RESULTS

A total of 3140 articles were included. Since 2015, publications on this topic have shown a significant upward trend. The top three contributing countries were China, the United States, and Italy. The International Journal of Molecular Sciences ranked first in terms of publication volume and total citations. A 2017 review titled "Parkinson's Disease" received the most citations. Keyword co-occurrence analyses revealed that research hotspots include abnormal aggregation of α-synuclein, mitochondrial dysfunction, oxidative stress, neuroinflammation, dysregulation of the autophagy-lysosome system and gene mutations. Recent trends indicate a clear shift from isolated molecular pathways toward systemic mechanisms, particularly highlighting the emerging roles of the gut-brain axis and ferroptosis in PD pathogenesis.

CONCLUSION

Research on the pathogenesis of Parkinson's disease has gained increasing attention. This study presents a bibliometric analysis and visualization of global research trends and hotspots over the past decade, providing valuable perspectives for future studies into PD-related mechanisms.