[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 2002
[An experimental study of inhibition of tetrandrine on posterior capsular opacification in rabbits].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Guo Linjie, Zhang Xiaofang, Zhang Sheng
Аннотация
OBJECTIVE: To study the effect of tetrandrine (Tet) on the formation of posterior capsular opacification (PCO) after cataract extraction.
METHODS: Intraocular lens implantation was performed on 48 healthy rabbit eyes, and they were randomly divided into 4 groups: control (A), dexamethasone (B), Tet (C) and Tet with coated IOL (D). Dexamethasone and Tet were postoperatively injected into the subconjunctival space. The number of cells, the contents of protein and malondialdehyde (MDA) in the aqueous were determined at different days postoperatively. The PCO was scored and opaque posterior capsules were weighted.
RESULTS: The number of cells, the amount of protein in aqueous, the scales and the wet weight of PCO in the treated eyes were less than that of the control eyes (P < 0.05). In B and C group, except the 14th day content, the postoperative MDA was lower than that in the control group (P < 0.05).
CONCLUSION: Tet can inhibit the formation of PCO, and has no obvious toxicity to the corneal endothelium.
METHODS: Intraocular lens implantation was performed on 48 healthy rabbit eyes, and they were randomly divided into 4 groups: control (A), dexamethasone (B), Tet (C) and Tet with coated IOL (D). Dexamethasone and Tet were postoperatively injected into the subconjunctival space. The number of cells, the contents of protein and malondialdehyde (MDA) in the aqueous were determined at different days postoperatively. The PCO was scored and opaque posterior capsules were weighted.
RESULTS: The number of cells, the amount of protein in aqueous, the scales and the wet weight of PCO in the treated eyes were less than that of the control eyes (P < 0.05). In B and C group, except the 14th day content, the postoperative MDA was lower than that in the control group (P < 0.05).
CONCLUSION: Tet can inhibit the formation of PCO, and has no obvious toxicity to the corneal endothelium.